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A study is being conducted by researchers at Emory University to test a vaccine against Shigella bacteria.
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Shigella is a common and sometimes deadly stomach bug that can cause symptoms such as diarrhea, stomach pain, and fever.
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It can cause severe and potentially fatal complications, especially in people with weakened immune systems.
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Shigella is a major public health threat worldwide, leading to over 200,000 deaths annually.
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Antibiotics are used to treat Shigella, but antibiotic-resistant strains are emerging.
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The vaccine being tested is an oral vaccine made from a weakened form of Shigella bacteria.
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The study is a human challenge trial, meaning participants will be exposed to the bacteria and the possibility of illness.
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Participants will be divided into three groups, with one group receiving two doses of the vaccine and another receiving one vaccine dose and a placebo.
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Participants will be monitored in the hospital for up to 11 days and will be required to attend up to 14 outpatient study visits.
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Participants can earn up to $4,250 for completing the study, which is being conducted at Emory’s Hope Clinic in Georgia and Cincinnati Children’s Hospital Medical Center in Ohio.